Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.
Chronically elevated levels of fatty acids-FA can cause beta cell Eyebright death in vitro.Beta cells vary in their individual susceptibility to FA-toxicity.Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased triglyceride formation or mitochondrial and peroxisomal FA-oxidation, possibly reducing cytoplasmi